#5179 LESS MICROBUBBLES ENTERED THE PATIENTS USING THE VENOUS CHAMBER EMBOLESS DURING HAEMODIALYSIS

Abstract Background and Aims The extracorporeal circuit (ECC) enables haemodialysis (HD) of patients. Air contamination the blood appears when it passes ECC consequently microbubbles (MBs) enter to patient [1]. MBs were verified at autopsy HD patients covered by clots as microemboli deposited within tissue from lungs, heart brain [2]. A venous chamber is inserted in reduce MBs. However, chambers clinical use have limited capacity eliminate entering return bloodline. In an vitro preclinical study Emboless showed best results compared common models use; those was for Fresenius 5008 [3]. We if differs limit MB exposure original (F5008). Method Thirty-eight HDs performed 19 paired sessions. Eleven included. Venous used either F5008 or Emboless, a randomised order. Dialyzers, blood-pump speed, HDF ultrafiltration kept similar between pairs. Microbubbles measured ‘Inlet’ ‘Outlet’ with ultrasound device adjusted (hil mode, BCC200, GAMPT). Measurements made all sizes 20µm-500µm diameter. If first 30min subsequent (extended time less than 1000 detected inlet MBs). percentage change versus counts (paired Wilcoxon test). Total reduction -100% while increase (worsened) caused unlimited (+) percentage. diameter without not included analysis. Results median overall −33% (mean −20 ±76%, N = 8544) -69% -56 ±54%, 8402; pairwise 8093, p<0.001). Table 1 shows more results. Conclusion Less subsequently entered using EmbolessTM during haemodialysis. Considering our previous studies2 this supports damage EmbolessTM.